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The UCL Centre for Amyloidosis & Acute Phase Proteins has identified the cause and treatment for the prototypical cryopryin associated periodic syndrome (CAPS), and subsequently for a range of other hereditary and acquired autoinflammatory disorders.
Pioneering UCL research in the 1990s into the mechanisms that cause rheumatoid arthritis established a new understanding of the disease. As a result, a new treatment – B cell depletion – has been introduced worldwide.
The ATAC trial of a novel breast cancer treatment has resulted in a dramatic, global change in the management of the disease.
Research at UCL on human haemolytic anaemias, known as the ‘hereditary stomatocytoses’, has improved diagnosis of these conditions, and has raised awareness of the potential impact on donated blood.
Investigation of the role of CT colonography led to this examination replacing the standard radiological alternative of barium enema in the UK National Bowel Cancer Screening Programme and for symptomatic patients in the NHS.
CardioQ: Improved surgical outcomes achieved through perioperative circulatory optimisation guided by oesophageal Doppler
A new device – the CardioQ Oesophageal Doppler Monitor – used to monitor critically ill patients and those undergoing high-risk surgery has been used for over half a million patients and is recommended in NICE guidance.
Researchers at the UCL Centre for Rheumatology & Connective Tissue Disease have pioneered translational research in systemic sclerosis, resulting in better stratification, management and treatments for the condition.
Research has led to advances in the diagnosis of amyloidosis and clinical characterisation of many new subtypes that has led to new standards of clinical care, improved diagnosis, improved outcomes, and major investment by the NHS.
Professor Sir Mark Pepys and his team in the UCL Wolfson Drug Discovery Unit have invented new chemical entities for treatment of amyloidosis, Alzheimer’s disease, and other conditions.
As a result of research on acid-sensing ion channels (ASICs) in pain regulation, ASIC-related therapies for a wide variety of conditions are now in clinical trials.