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1 - 4 of 4 results found for ABCB4. Did you mean: abca4

  1. Trafficking and transporter disorders in pediatric cholestasis.

    This article describes the uses of immunostaining in the diagnosis of cholestasis. To immunostain for bile salt export pump (BSEP) and multidrug resistance protein 3 in severe hepatobiliary disease manifest early in life can rapidly identify whether

  2. ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in...

    BACKGROUND: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these

  3. Exon sequencing and high resolution haplotype analysis of ABC transporter genes...

    BACKGROUND: The ATP-binding cassette (ABC) proteins are a superfamily of efflux pumps implicated as a mechanism for multidrug resistance in cytotoxic chemotherapy, immunosuppressive therapy, HIV and epilepsy. Genetic variation in P-glycoprotein, the

  4. Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a...

    BACKGROUND: The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed

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