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1 - 4 of 4 results found for DDB1. Did you mean: drb1

  1. The Potential of MLN3651 in Combination with Selumetinib as a Treatment for...

    Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex,

    http://iris.ucl.ac.uk/iris/publication/1796139/1

  2. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

    © 2020, The Author(s), under exclusive licence to Springer Nature Limited. Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors,

    http://iris.ucl.ac.uk/iris/publication/1790862/1

  3. Genomic profiling of pediatric ALK-positive anaplastic large cell lymphoma: a...

    Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T-cell malignancy in which ALK expression is a consequence of the t(2;5) or a variant translocation involving Chromosome 2. For the most part, this disease presents

    http://iris.ucl.ac.uk/iris/publication/841114/1

  4. G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4...

    UNLABELLED: The accessory gene vpr, common to all primate lentiviruses, induces potent G2/M arrest in cycling cells. A recent study showed that human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) mediates this through activation of the

    http://iris.ucl.ac.uk/iris/publication/985944/2

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