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1 - 4 of 4 results found for DDX3X.

  1. Relax, Don't RAN Translate It.

    The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019)

  2. PATTERSON, James O | MBPhD Programme - UCL – University College London

    By setting out to create novel mutant alleles for four of the X-linked genes from the X-Y pairs — Kdm5c, Kdm6a, Ddx3x, and Eff 2s3x — using CRISPR-Cas genome editing,

  3. Characterisation of the Genomic Landscape of CRLF2-rearranged Acute Lymphoblastic...

    Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We aimed to determine the clinical and genetic landscape of those with IGH-CRLF2 or P2RY8-CRLF2 (CRLF2-r)

  4. Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation.

    OBJECTIVE: Determining the genetic basis of speech disorders provides insight into the neurobiology of human communication. Despite intensive investigation over the past 2 decades, the etiology of most speech disorders in children remains unexplained

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