Advanced search

1 - 10 of 20 results found for DNMT1. Did you mean: dmt1

  1. A phase I and pharmacodynamic study of a 7 day infusion schedule of the DNMT1 antisense...

  2. DNMT1 interacts with the developmental transcriptional repressor HESX1

    Hesx1 is a highly conserved homeobox gene present in vertebrates, but absent from invertebrates. Gene targeting experiments in mice have shown that this transcriptional repressor is required for normal forebrain and pituitary development. In humans,

  3. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders


  5. The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in...

    Inverted CCAAT box-binding protein of 90 kDa (ICBP90) is over-expressed in several types of cancer, including breast, prostate and lung cancers. In search for proteins that interact with the set and ring-associated (SRA) domain of ICBP90, we used

  6. DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident...

    The genome of extraembryonic tissue, such as the placenta, is hypomethylated relative to that in somatic tissues. However, the origin and role of this hypomethylation remains unclear. The DNA methyltransferases DNMT1, -3A, and -3B are the primary

  7. Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a...

    OBJECTIVE: Hepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this process. Concerted action between histone and

  8. Correlations among PPARγ, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer.

    Emerging evidence indicates that peroxisome proliferator-activated receptor γ (PPARγ) and DNA methyltransferases (DNMTs) play a role in carcinogenesis. In this study we aimed to evaluate the expression of PPARγ, DNMT1, and DNMT3B and their

  9. Publications | UCL Great Ormond Street Institute of Child Health -...

    Copp. Development (2007). DNMT1 interacts with the developmental transcriptional repressor HESX1.Ezat Sajedi, Carles Gaston-Massuet, Cynthia L.

  10. A novel requirement for DROSHA in maintenance of mammalian CG methylation

    In mammals, faithful inheritance of genomic methylation patterns ensures proper gene regulation and cell behaviour, impacting normal development and fertility. Following establishment, genomic methylation patterns are transmitted through S-phase by

  11. Page: 1 2