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  1. Variable FHIT transcripts in non-neoplastic tissues.

    We used nested reverse transcriptase PCR to investigate the expression of the FHIT gene, a presumptive tumor suppressor gene located in chromosomal band 3p 14.2, in non-neoplastic samples. Multiple transcripts of the FHIT gene were found in

  2. Analysis of FHIT gene expression in oral squamous cell carcinomas


  3. High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in...

  4. Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

  5. The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated...

    We have used nested reverse transcription-PCR (RT-PCR) and PCR on genomic DNA to search for aberrations in the FHIT and PTPRG genes, both located in chromosomal band 3p14.2, in specimens from cytogenetically analyzed benign breast lesions (three

  6. Bill Lyons Informatics Centre team | UCL Cancer Institute - UCL –...

    AID, APOBECs) and disregulated DNA repair (e.g. FHIT, XRCC1). My specific skills are in programming R (OK) and Python (less OK), enough statistical know-how to avoid the Dunning-Kruger

  7. Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X...

    We previously reported the identification of three minimal regions of deletion on the short arm of chromosome 3 (3p) in epithelial ovarian tumor specimens, suggesting that the inactivation of tumor-suppressor genes in these regions may be important

  8. Genome-wide association uncovers shared genetic effects among personality traits and mood...

    Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (~2.5 million) and gene-based association analyses of these traits and examined the overlap in results across

  9. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad...

    BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes

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