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  1. Identification of novel FLI1 mutations in two families with a platelet secretion defect

  2. Published Research | UCL Cancer Institute - UCL – University College...

    Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.

  3. FLI1 monoallelic expression combined with its hemizygous loss underlies...

    Paris-Trousseau syndrome (PTS; also known as Jacobsen syndrome) is characterized by several congenital anomalies including a dysmegakaryopoiesis with two morphologically distinct populations of megakaryocytes (MKs). PTS patients harbor deletions on

  4. No EWS/FLI1 fusion transcripts in giant-cell tumors of bone.

    Giant-cell tumor of bone (GCT) is a locally aggressive neoplasm of unknown etiology and pathogenesis. Cytogenetically, no consistent chromosomal alterations, apart from telomeric associations involving various chromosome ends, have been described.

  5. The Pro-Oncoprotein EWS (Ewing's Sarcoma Protein) Interacts with the Brn-3a POU...

    The Brn-3a POU family transcription factor is able to induce the expression of a number of neuronally-expressed genes as well as to enhance neuronal differentiation and inhibit apoptosis. Many of these effects are mediated by the C-terminal POU

  6. [Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis...

    There may be a number of tumors made up by small round blue cells in the kidneys of children. One of them is primitive neuroectodermal tumor (PNET). The differences in therapeutic approaches determine the need to establish an accurate diagnosis. The

  7. High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic...

    Many solid tumors exhibit characteristic gene fusions, which are reflected by balanced translocations at the cytogenetic level. These changes might be useful diagnostic and prognostic tools. In Wilms tumor (WT, nephroblastoma) no fusions genes or

  8. Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a...

    The developmental receptor NOTCH plays an important role in various human cancers as a consequence of oncogenic mutations. Here we describe a novel mechanism of NOTCH-induced tumor suppression involving modulation of the deacetylase SIRT1, providing

  9. Ewing sarcoma: Current management and future approaches through collaboration

    Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak incidence in adolescents and young adults. The treatment of ES relies on a multidisciplinary approach, coupling risk-adapted intensive neoadjuvant

  10. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny

    © 2017.Hematopoietic stem cells (HSCs) emerge during development via an endothelial-to-hematopoietic transition from hemogenic endothelium of the dorsal aorta (DA). Using in situ hybridization and analysis of a knock-in RedStar reporter, we show

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