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1 - 10 of 13 results found for GLDC. Did you mean: glc

  1. Non-Ketotic Hyperglycinemia and the Glycine Cleavage System | UCL...

    We also analyse mice carrying one copy of each gene-trap construct (Gldc. ... Using conditional genetic rescue to examine the requirement for GLDC activity in specific tissues.

    https://www.ucl.ac.uk/child-health/research/developmental-biology-and-cancer
    /developmental-biology-birth-defects/andrew-copps-and-0

  2. Cellular and metabolic basis of brain dysfunction in inherited...

    The aim of the project is understand how loss of GLDC causes neurological deficits in babies and children with NKH. ... The student will make use of mouse genetic models which carry gene-trap and CRISPR-induced missense mutations in GLDC.

    https://www.ucl.ac.uk/child-health
    /cellular-and-metabolic-basis-brain-dysfunction-inherited-childhood-neurological-disease

  3. Use of high frequency ultrasound to study the prenatal development of cranial neural tube...

    OBJECTIVE: We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD: Using HFUS, we imaged embryos carrying

    http://iris.ucl.ac.uk/iris/publication/1201485/1

  4. Folate one-carbon metabolism and neural development | UCL Great...

    Mol. Genet. 2012; Pai YJ et al, Nat. Commun. 2015).  .  . CURRENT WORK INCLUDES:. Studies to determine how loss of function of glycine decarboxylase (Gldc) causes NTDs. ... We are using a Gldc-deficient mouse model to investigate Non-Ketotic

    https://www.ucl.ac.uk/child-health/research/developmental-biology-and-cancer
    /developmental-biology-birth-defects/andrew-copps-and-3

  5. Genome‐wide association study identifies the GLDC/IL33 locus associated with survival of...

    Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi‐institutional genome‐wide association study

    http://iris.ucl.ac.uk/iris/publication/1519546/1

  6. The glycine cleavage system in embryonic brain development

    The glycine cleavage system (GCS) is a multi-enzyme complex localised in the mitochondria and serves as the main catabolic pathway for glycine. It contributes to supply of one-carbon units into folate one-carbon metabolism (FOCM) which utilises them

    http://iris.ucl.ac.uk/iris/publication/1052426/1

  7. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway...

    Glycine abundance is modulated in a tissue-specific manner by use in biosynthetic reactions, catabolism by the glycine cleavage system (GCS) and excretion via glycine conjugation. Dysregulation of glycine metabolism is associated with multiple

    http://iris.ucl.ac.uk/iris/publication/1806266/1

  8. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for...

    Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore

    http://iris.ucl.ac.uk/iris/publication/1509318/1

  9. Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying...

    Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine. Mutation of AMT or GLDC,

    http://iris.ucl.ac.uk/iris/publication/1844514/1

  10. Mutations in genes encoding the glycine cleavage system predispose to neural tube defects...

    Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects of the central nervous system. The complex multigenic causation of human NTDs, together with the large number of possible candidate genes, has hampered

    http://iris.ucl.ac.uk/iris/publication/355092/1

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