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1 - 10 of 16 results found for GSTP1. Did you mean: gstm1

  1. Association of molecular markers with toxicity outcomes in a randomized trial of...

    Purpose: Predicting efficacy and toxicity could potentially allow individualization of cancer therapy. We investigated putative pharmacogenetic markers of chemotherapy toxicity in a large randomized trial. Patients, Materials, and Methods: Patients

    http://iris.ucl.ac.uk/iris/publication/875990/7

  2. Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness:...

    BACKGROUND: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung function. However, little

    http://iris.ucl.ac.uk/iris/publication/938374/2

  3. Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression...

    Flavonoids from fruits and vegetables probably reduce risks of diseases associated with oxidative stress, including cancer. Apples contain significant amounts of flavonoids with antioxidative potential. The objectives of this study were to

    http://iris.ucl.ac.uk/iris/publication/965479/2

  4. Germline genetic polymorphisms may influence chemotherapy response and disease outcome in...

    BACKGROUND: Osteosarcoma is the most common malignant bone tumor in children and young people. Efficacy of multiagent MAP (methotrexate, doxorubicin [Adriamycin], cisplatin) chemotherapy may be influenced by multiple cellular pathways. This pilot

    http://iris.ucl.ac.uk/iris/publication/404322/7

  5. A pilot pharmacogenomics study examining the influence of cytotoxic and metabolising...

    Background: Osteosarcoma is the most common malignant bone tumour in children and young people. Multi-agent MAP chemotherapy (Methotrexate, Adriamycin, cisPlatin) forms the backbone of standard treatment protocols but approximately 40% patients

    http://iris.ucl.ac.uk/iris/publication/854832/1

  6. ABCB1 c.3435C>T polymorphism is associated with platinum toxicity: a preliminary...

    © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Background: Platinum-based doublets are the standard chemotherapy for lung cancer. The identification of markers associated with drug toxicity may improve the success of the treatment.

    http://iris.ucl.ac.uk/iris/publication/1640559/1

  7. Pharmacogenetic analysis of the UK MRC MAGIC trial: association of polymorphisms with...

    Germline polymorphisms may affect chemotherapy efficacy and toxicity. We examined the effect of polymorphisms in drug metabolism and DNA repair genes on pathological response rates, survival, and toxicity for patients randomised to surgery alone or

    http://iris.ucl.ac.uk/iris/publication/1426649/1

  8. Apple polyphenols modulate expression of selected genes related to toxicological defence...

    Apples contain significant amounts of flavonoids that are potentially cancer risk reducing by acting antioxidative or antiproliferative and by favorably modulating gene expression. The purpose of this study was to investigate whether polyphenols

    http://iris.ucl.ac.uk/iris/publication/965476/2

  9. Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core...

    BACKGROUND AND AIM: The mechanisms of hepatocarcinogenesis induced by hepatitis C virus remain unclear. Our aim was to investigate the effect of the HCV core protein on the promoter methylation status of selected genes potentially involved in the

    http://iris.ucl.ac.uk/iris/publication/850948/2

  10. Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells.

    Anti-inflammatory properties of azithromycin (AZM) have been proposed as possible mechanisms of clinical beneficial effects in patients with cystic fibrosis (CF). Altered glutathione (GSH) transport in cystic fibrosis transmembrane regulator protein

    http://iris.ucl.ac.uk/iris/publication/172399/2

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