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1 - 10 of 15 results found for HCN4. Did you mean: hcn

  1. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels

  2. A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate.

    BACKGROUND: Heart rate follows a diurnal variation and slow heart rhythms occur primarily at night. OBJECTIVE: The lower heart rate during sleep is assumed to be neural in origin but here we tested whether a day-night difference in intrinsic

  3. Cardiovascular Gene Annotation | UCL Institute of Cardiovascular...

    Q8N335. 39. GSTM2. glutathione S-transferase mu 2. P28161. 40. HCN4. hyperpolarization activated cyclic nucleotide gated potassium channel 4. ... HCN4.  . hsa-miR-1. KCNE1.  . hsa-miR-1. KCNB2.  . hsa-miR-1. KCNJ2. 2.

  4. A genetic model of ivabradine recapitulates results from randomized clinical trials.

    BACKGROUND: Naturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure

  5. Molecular analysis of patterning of conduction tissues in the developing human heart

    Background-Recent studies in experimental animals have revealed some molecular mechanisms underlying the differentiation of the myocardium making up the conduction system. To date, lack of gene expression data for the developing human conduction

  6. Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel


    In the human, there is a circadian rhythm in the resting heart rate and it is higher during the day in preparation for physical activity. Conversely, slow heart rhythms (bradyarrhythmias) occur primarily at night. Although the

  7. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.

    The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We

  8. The extent of the specialized atrioventricular ring tissues

    Background: The so-called specialized tissues within the heart are the sinus node, the atrioventricular conduction system, and the Purkinje network. Further structures with the characteristics of specialized tissue are also found within the

  9. Role of the hyperpolarization-activated current Ih in somatosensory neurons.

    The hyperpolarization-activated current (I(h)) is an inward current activated by hyperpolarization from the resting potential and is an important modulator of action potential firing frequency in many excitable cells. Four hyperpolarization-activated

  10. Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes...

    Cardiac mesoangioblasts (MABs) are a class of vessel-associated clonogenic, self-renewing progenitor cells, recently identified in the post-natal murine heart and committed to cardiac differentiation. Cardiomyocytes generated during cardiogenesis

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