Advanced search

1 - 6 of 6 results found for HDAC3. Did you mean: hdac

  1. Genetic Knock-Down of Hdac3 Does Not Modify Disease-Related Phenotypes in a Mouse Model...

  2. Alison Lloyd | LMCB - MRC Laboratory for Molecular Cell Biology

    Development 145, dev170316. Rosenberg NH, et al (2018).  HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State.

  3. HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State

    © 2018 The Author(s) The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability

  4. Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by...

    RATIONALE: Nkx2.5 is one of the most widely studied cardiac-specific transcription factors, conserved from flies to man, with multiple essential roles in both the developing and adult heart. Specific dominant mutations in NKX2.5 have been identified

  5. Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor

    © 2019 Elsevier Masson SAS Herein, we report the discovery of a dual histone deacetylase inhibitor displaying a unique HDAC3/6 selectivity profile. An initial strategy to merge two epigenetic pharmacophores resulted in the discovery of potent HDAC6

  6. Histone deacetylase inhibitors containing chiral heterocyclic capping groups

    Histone deacetylase (HDAC) enzymes are one of the best characterised epigenetic targets; aberrant activity of one or more of the 11 zinc-dependent HDAC isoforms has been associated with many different cancers, as well as several other diseases. Some

  7. Page: 1