Related to LRP6
Advanced search
Search:  

1 - 10 of 12 results found for LRP6. Did you mean: lrp

  1. Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome

    http://iris.ucl.ac.uk/iris/publication/901143/11

  2. Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt...

    http://iris.ucl.ac.uk/iris/publication/109573/1

  3. LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and...

    Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a frequent cause of Parkinson's disease (PD). Nonetheless, the physiological role of LRRK2 remains unclear. Here, we demonstrate that LRRK2 participates in canonical Wnt

    http://iris.ucl.ac.uk/iris/publication/652051/1

  4. Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer's Disease: Emerging...

    Synapse dysfunction and loss represent critical early events in the pathophysiology of Alzheimer's disease (AD). While extensive research has elucidated the direct synaptotoxic effects of Amyloid-β (Aβ) oligomers, less is known about how signaling

    http://iris.ucl.ac.uk/iris/publication/1602310/1

  5. Contribution of a genetic variant of the Wnt receptor LRP6 to synapse vulnerability in...

    Synapse dysfunction and loss represent key pathological hallmarks of Alzheimer's disease (AD). Wnt signalling, in particular through the Wnt co-receptor LRP6, has a critical role in maintaining the structural and functional integrity of synaptic

    http://iris.ucl.ac.uk/iris/publication/1532055/1

  6. Professor Kirsten Harvey | UCL School of Pharmacy - UCL – University...

    J Biol Chem 289:895-908. Berwick DC, Harvey K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

    https://www.ucl.ac.uk/pharmacy/people/professor-kirsten-harvey

  7. LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations...

    Cenani-Lenz syndrome (CLS) is an autosomal-recessive congenital disorder affecting distal limb development. It is characterized mainly by syndactyly and/or oligodactyly and is now shown to be commonly associated with kidney anomalies. We used a

    http://iris.ucl.ac.uk/iris/publication/223737/2

  8. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in...

    Aggressive behaviours of solid tumours are highly influenced by the tumour microenvironment. Multiple signalling pathways can affect the normal function of stromal fibroblasts in tumours, but how these events are coordinated to generate

    http://iris.ucl.ac.uk/iris/publication/1621729/1

  9. Plasma membrane recruitment of dephosphorylated β-catenin upon activation of the Wnt...

    The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing β-catenin to accumulate in the cytosol and nucleus and

    http://iris.ucl.ac.uk/iris/publication/1549298/7

  10. Wnt signalling in an in vitro niche model for conjunctival progenitor cells.

    Mimicking an environment in vitro that is more similar to the stem cell niche in vivo, by co-culture of mitotically active conjunctival fibroblasts (HCF) with human conjunctival epithelial cells (HCECs), improves the maintenance of epithelial cells

    http://iris.ucl.ac.uk/iris/publication/825383/2

  11. Page: 1 2