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  1. Amplification of MDM2 and MDM4 in Osteosarcoma

    http://iris.ucl.ac.uk/iris/publication/293295/3

  2. High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers...

    http://iris.ucl.ac.uk/iris/publication/290873/1

  3. Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification...

    http://iris.ucl.ac.uk/iris/publication/352344/3

  4. Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification...

    http://iris.ucl.ac.uk/iris/publication/352344/2

  5. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early...

    We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10.5 days postcoitum [dpc]), which was rescued by transferring the Mdm4 mutation

    http://iris.ucl.ac.uk/iris/publication/248676/2

  6. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth

    http://iris.ucl.ac.uk/iris/publication/1694036/3

  7. Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces...

    p53 is a tumor suppressor, which belongs to the p53 family of proteins. The family consists of p53, p63 and p73 proteins, which share similar structure and function. Activation of wild-type p53 or TAp73 in tumors leads to tumor regression, and small

    http://iris.ucl.ac.uk/iris/publication/1642736/1

  8. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53...

    Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or through aberrant expression of proteins acting in the p53 pathway, such as p14(ARF) or Mdm2. A role for Mdmx (or Mdm4) as

    http://iris.ucl.ac.uk/iris/publication/248714/2

  9. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and...

    p53 is a guardian of the genome that protects against carcinogenesis. There is accumulating evidence that p53 is activated with aging. Such activation has been reported to contribute to various age-associated pathologies, but its role in vascular

    http://iris.ucl.ac.uk/iris/publication/1631696/1

  10. Loci influencing blood pressure identified using a cardiovascular gene-centric array

    Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ~50 000 single

    http://iris.ucl.ac.uk/iris/publication/863026/7

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