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1 - 10 of 33 results found for PARK2.

  1. PARK2 presenting as a disabling peripheral axonal neuropathy.

    http://iris.ucl.ac.uk/iris/publication/1501027/2

  2. The familial Parkinson disease gene PARK2 is a multisite tumor suppressor on chromosome...

    http://iris.ucl.ac.uk/iris/publication/965470/2

  3. Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG...

    http://iris.ucl.ac.uk/iris/publication/1587067/3

  4. Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma...

    Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common cause of early-onset Parkinson's disease. In a search for multisite tumor suppressors, we identified PARK2 as a frequently targeted gene on chromosome 6q25.2-q27 in

    http://iris.ucl.ac.uk/iris/publication/965471/2

  5. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN...

    http://iris.ucl.ac.uk/iris/publication/1280917/3

  6. Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.

    Coordinate control of different classes of cyclins is fundamentally important for cell cycle regulation and tumor suppression, yet the underlying mechanisms are incompletely understood. Here we show that the PARK2 tumor suppressor mediates this

    http://iris.ucl.ac.uk/iris/publication/965466/2

  7. The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case...

    Mutations in the PARK2 gene have been implicated in the pathogenesis of early-onset Parkinson's disease. We present a case of movement disorder in a 4-year-old child from consanguineous parents and with a family history of Dopamine responsive

    http://iris.ucl.ac.uk/iris/publication/1664437/1

  8. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma...

    In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a

    http://iris.ucl.ac.uk/iris/publication/1758388/7

  9. The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN- dependent...

    Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic e3 ubiquitin-protein ligase PaRK2 cooperates with the mitochondrial kinase PiNK1 to maintain mitochondrial quality. a

    http://iris.ucl.ac.uk/iris/publication/1108355/7

  10. Heterozygote carriers for CNVs in PARK2 are at increased risk of Parkinson's disease

    Together with point mutations, homozygous deletions or duplications in PARK2 are responsible for the majority of autosomal recessive juvenile Parkinsonism. It is debated, however, whether heterozygous carriers of these mutations are at increased

    http://iris.ucl.ac.uk/iris/publication/1826921/7

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