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1 - 9 of 9 results found for PFKFB3.

  1. Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate...

    During cell proliferation, the abundance of the glycolysis-promoting enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3 (PFKFB3), is controlled by the ubiquitin ligase APC/C-Cdh1 via a KEN box. We now demonstrate in synchronized

  2. The regulatory role of APC/C-Cdh1 in proliferating and differentiating pre-adipocytes

    It is well known that proliferating cells, whether they are normal or malignant, exhibit increased glycolysis and glucose uptake. Breakdown of glucose through the glycolytic cascade not only yields essential precursors for macromolecule biosynthesis

  3. Molecular basis for the differential use of glucose and glutamine in cell proliferation...

    During cell division, the activation of glycolysis is tightly regulated by the action of two ubiquitin ligases, anaphase-promoting complex/cyclosome-Cdh1 (APC/C-Cdh1) and SKP1/CUL-1/F-box protein-β-transducin repeat-containing protein (SCF-β-TrCP),

  4. Fulfilling the metabolic requirements for cell proliferation.

    The activity of key metabolic enzymes is regulated by the ubiquitin ligases that control the function of the cyclins; therefore the activity of these ubiquitin ligases explains the coordination of cell-cycle progression with the supply of substrates

  5. Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis.

    BACKGROUND: Although neoangiogenesis is a hallmark of chronic inflammatory diseases such as inflammatory arthritis and many cancers, therapeutic agents targeting the vasculature remain elusive. Here we identified miR-125a as an important regulator

  6. Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with...

    Cell proliferation is accompanied by an increase in the utilization of glucose and glutamine. The proliferative response is dependent on a decrease in the activity of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdh1 which

  7. Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models.

    Meclizine is a well-tolerated drug routinely used as an anti-histamine agent in the management of disequilibrium. Recently, meclizine has been assessed for its neuroprotective properties in ischemic stroke and Huntington disease models. We found

  8. Cell metabolism sets the differences between subpopulations of satellite cells (SCs).

    BACKGROUND: We have recently characterized two distinct populations of Satellite Cells (SCs) that differ in proliferation, regenerative potential, and mitochondrial coupling efficiency and classified these in Low Proliferative Clones (LPC) and High

  9. Mitochondrial and potassium channel dysfunction in pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a rare, progressive and potentially fatal cardiopulmonary disorder, characterised by extensive remodelling and luminal narrowing of the small pulmonary arteries. Central to this remodelling is the

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