1 - 5 of 5 results found for PSMC1. Did you mean: pasmcs
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TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory...
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Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and...
Ubiquitin-positive intraneuronal inclusions are a consistent feature of the major human neurodegenerative diseases, suggesting that dysfunction of the ubiquitin proteasome system is central to disease etiology. Research using inhibitors of the 20S
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The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen...
In the past twenty years, evidence has accumulated to show that ubiquitinated proteins are a consistent feature of the intraneuronal protein aggregates (inclusions) that characterize chronic neurodegenerative disease. These findings may indicate
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Identification of Interacting Protein Partners of TOPORS in the Retina
Retinitis pigmentosa (RP, MIM#268000) is a heterogeneous disease characterised by loss of rod photoreceptors and pigment deposits in the retina. Historically, genes linked to RP were associated with rod-specific functions. Recently, a novel class of
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Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins...
USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has been considered a therapeutic strategy for accelerating degradation of
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