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  1. Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored...


  3. Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

    © 2020 The Author(s) Cell fate transitions are frequently accompanied by changes in cell shape and mechanics. However, how cellular mechanics affects the instructive signaling pathways controlling cell fate is poorly understood. To probe the

  4. Functional CSF-1 receptors are located at the nuclear envelope and activated via the...

    Colony stimulating factor-1 (CSF-1) and its receptor (CSF-1R) are key regulators of macrophage biology, and their elevated expression in cancer cells has been linked to poor prognosis. CSF-1Rs are thought to function at the plasma membrane. We show

  5. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the...

    Mutations that activate the LRRK2 protein kinase, predispose to Parkinson's disease, suggesting that LRRK2 inhibitors might have therapeutic benefit. Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10,

  6. Membrane binding, internalization, and sorting of alpha-synuclein in the cell

    Alpha-synuclein (aSyn) plays a crucial role in Parkinson's disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle binding and

  7. Plasma membrane and cell surface mechanics in embryonic stem cells

    Changes in cell shape frequently accompany cell fate transitions. Cell shape changes are regulated by cell surface mechanics. One of the main determinants of cell surface mechanics is membrane tension, which is regulated by the interaction between

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