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1 - 10 of 14 results found for RAF1. Did you mean: raff

  1. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa...

    We report genetic aberrations that activate the ERK/MAP kinase pathway in 100% of posterior fossa pilocytic astrocytomas, with a high frequency of gene fusions between KIAA1549 and BRAF among these tumours. These fusions were identified from

  2. G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the...

    The G protein-coupled receptor kinases (GRKs) are best known for their role in phosphorylating and desensitizing G protein-coupled receptors (GPCRs). The GRKs also regulate signaling downstream of other families of receptors and have a number of

  3. CSIR - Centre for Cellular and Molecular Biology,  Hyderabad | Queen...

    Matsuoka R, Thangaraj K, Gelb BD (2014) RAF1 mutations cause dilated cardiomyopathy.

  4. Linkage analysis and exclusion of regions of chromosomes 3 and 8 in Gilles de la Tourette...

    Gilles de la Tourette syndrome (GTS) and related disorders such as chronic multiple tics and obsessive compulsive behaviour are likely to be genetically transmitted with a Mendelian autosomal dominant mode of transmission. Following our discovery of

  5. Unraveling the complexity of endocrine resistance in breast cancer by functional genomics.

    Despite the proven benefit of antiestrogen drugs in breast cancer treatment, resistant disease ultimately develops in advanced breast cancer. In this issue of Cancer Cell, Iorns et al. find that loss of CDK10 expression promotes resistance of cells

  6. MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway.

    The MAPK/ERK signalling pathway has been described to mediate IL-1 induction of target genes and is known to be regulated by microRNAs (miRNA). We describe a novel miRNA regulating the expression of the MEK1 gene and how it impacts IL-1 induced IL-6

  7. Regulation of growth and survival of activated T cells by cell-transducing inhibitors of...

    We describe the development of cell-penetrating inhibitors of Ras and study their ability to inhibit T cell activation. The inhibitors transduced T cells in a time and concentration-dependent manner and interacted with endogenous Ras.

  8. Long range restriction map of the von Hippel-Lindau gene region on human chromosome 3p

    Von Hippel-Lindau disease is a heritable tumour syndrome caused by the loss of the function of a tumour suppressor gene on the short arm of human chromosome 3. The interval RAF1-D3S18 (3p25-3p26) has been identfied by genetic linkage studies to

  9. Prevalence of sequence variants in the RAS-mitogen activated protein kinase signaling...

    BACKGROUND: Most cases of apparently idiopathic hypertrophic cardiomyopathy (HCM) in children are caused by mutations in cardiac sarcomere protein genes. HCM also commonly occurs as an associated feature in some patients with disorders caused by

  10. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras...

    BACKGROUND: The small GTPase R-Ras displays a less potent transforming activity than the closely related Ras oncogene products. Although R-Ras has been reported to interact with c-Raf1 and Ral-GDS in vitro, the pathways by which it exerts its

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