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1 - 10 of 25 results found for RIPK1.

  1. Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling.

    The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different biological outcomes including gene activation and cell

    http://iris.ucl.ac.uk/iris/publication/1113704/1

  2. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and...

    RIPK1 (receptor-interacting serine/threonine kinase 1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical interest as a drug target. We report four patients from three unrelated families with

    http://iris.ucl.ac.uk/iris/publication/1571476/1

  3. Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase...

    NF-κB (nuclear factor κB) signaling is considered critical for single positive (SP) thymocyte development because loss of upstream activators of NF-κB, such as the IKK complex, arrests their development. We found that the compound ablation of RelA

    http://iris.ucl.ac.uk/iris/publication/1630435/1

  4. Benedict Seddon | Institute of Immunity and Transplantation - UCL –...

    RIPK1. Surprisingly, this function does not depend on NF-kB activation. Our future work is focused upon understanding how this pathway is regulated and controls normal T cell function in health ... Survival of Single Positive Thymocytes Depends upon

    https://www.ucl.ac.uk/immunity-transplantation/people/benedict-seddon

  5. Professor Benedict Seddon | Division of Infection and Immunity - UCL...

    Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.

    https://www.ucl.ac.uk/infection-immunity/people/professor-benedict-seddon

  6. The Henning Walczak Lab | UCL Cancer Institute - UCL – University...

    3.  Lafont E, et al,  Walczak H.-  TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.

    https://www.ucl.ac.uk/cancer/research/department-cancer-biology/henning-walczak-lab

  7. Resisting death - research reveals surprising link | Division of...

    In patients with disease, TNF can trigger cell death in tissues by targeting a protein called RIPK1, and this feeds the inflammatory process as part of a host defence mechanism. “ ... Links. Read the paper: Survival of Single Positive Thymocytes

    https://www.ucl.ac.uk/infection-immunity/news/2019/feb
    /resisting-death-research-reveals-surprising-link

  8. Resisting death - research reveals surprising link | Institute of...

    In patients with disease, TNF can trigger cell death in tissues by targeting a protein called RIPK1, and this feeds the inflammatory process as part of a host defence mechanism. “ ... Links. Read the paper: Survival of Single Positive Thymocytes

    https://www.ucl.ac.uk/immunity-transplantation/news/2019/feb
    /resisting-death-research-reveals-surprising-link

  9. TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in...

    © 2019, ADMC Associazione Differenziamento e Morte Cellulare. Melanoma cells are highly resistant to conventional genotoxic agents, and BRAFV600/MEK-targeted therapies as well as immunotherapies frequently remain inefficient. Alternative means to

    http://iris.ucl.ac.uk/iris/publication/1651595/1

  10. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in...

    © 2019, ADMC Associazione Differenziamento e Morte Cellulare. Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for

    http://iris.ucl.ac.uk/iris/publication/1647566/1

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