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  1. The premature ageing syndrome protein, WRN, is a 3'→5' exonuclease [3]

  2. About EPICentre | EPICentre - UCL – University College London

    EPICentre has strong industrial links, and is a member of the Willis Research Network ( WRN).

  3. Issue 4 - January 2009 | UCL Institute of Cardiovascular Science -...

    TERF2, TERF2IP, TERT, TINF2, TNKS, TNKS2, WRN) there was not enough time to annotated all of the proteins associated with this process.

  4. EPICentre: An Interdisciplinary Centre for Natural Hazards Resilience...

    A member of the Willis Research Network ( WRN), EPICentre has research projects across the globe with several international partners, and the World Bank.

  5. The spectrum of WRN mutations in Werner syndrome patients

    The International Registry of Werner syndrome ( has been providing molecular diagnosis of the Werner syndrome (WS) for the past decade. The present communication summarizes, from among 99 WS subjects, the spectrum of 50

  6. LMNA mutations in atypical Werner's syndrome

    Background: Werner's syndrome is a progeroid syndrome caused by mutations at the WRN helicase locus. Some features of this disorder are also present in laminopathies caused by mutant LMNA encoding nuclear lamin A/C. Because of this similarity, we

  7. Non-operative versus operative management of open fractures in the paediatric population:...

  8. Microwell arrays reveal cellular heterogeneity during the clonal expansion of transformed...

    We developed micromolded microwell arrays to study the proliferation and senescence of single cells. Microwell arrays were designed to be compatible with conventional cell culture protocols to simplify cell loading, cell culture, and imaging. We

  9. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex...

    G-Quadruplex DNAs are folded, non-Watson-Crick structures that can form within guanine-rich DNA sequences such as telomeric repeats. Previous studies have identified a series of trisubstituted acridine derivatives that are potent and selective

  10. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

    The DNA replication machinery invariably encounters obstacles that slow replication fork progression, and threaten to prevent complete replication and faithful segregation of sister chromatids. The resulting replication stress activates ATR, the

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