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51 - 60 of 62 results found for CETP.

  1. Gene-centric association signals for lipids and apolipoproteins identified via the...

    Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16

    http://iris.ucl.ac.uk/iris/publication/347473/1

  2. The use of meta-analysis risk estimates for candidate genes in combination to predict...

    Although the risk for coronary heart disease (CHD) associated with single SNPs is modest it has been suggested that, in combination, several common risk-associated alleles could lead to a substantially better heart disease risk prediction. We have

    http://iris.ucl.ac.uk/iris/publication/119568/1

  3. Gene-centric association signals for lipids and apolipoproteins identified via the...

    Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16

    http://iris.ucl.ac.uk/iris/publication/122639/1

  4. The use of meta-analysis risk estimates for candidate genes in combination to predict...

    Although the risk for coronary heart disease (CHD) associated with single SNPs is modest it has been suggested that, in combination, several common risk-associated alleles could lead to a substantially better heart disease risk prediction. We have

    http://iris.ucl.ac.uk/iris/publication/159905/2

  5. Integrated associations of genotypes with multiple blood biomarkers linked to coronary...

    Individuals at risk of coronary heart disease (CHD) show multiple correlations across blood biomarkers. Single nucleotide polymorphisms (SNPs) indexing biomarker differences could help distinguish causal from confounded associations because of their

    http://iris.ucl.ac.uk/iris/publication/347425/1

  6. Integrated associations of genotypes with multiple blood biomarkers linked to coronary...

    Individuals at risk of coronary heart disease (CHD) show multiple correlations across blood biomarkers. Single nucleotide polymorphisms (SNPs) indexing biomarker differences could help distinguish causal from confounded associations because of their

    http://iris.ucl.ac.uk/iris/publication/119564/1

  7. Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic...

    © 2017 Elsevier B.V.Background and aims Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination.

    http://iris.ucl.ac.uk/iris/publication/1208734/1

  8. Genetic factors associated with response of LDL subfractions to change in the nature of...

    A preponderance of dense low density lipoprotein (LDL) particles is associated with an increased risk of coronary heart disease. It has been shown that dense LDL levels can be modified by diet. We investigated the contribution of polymorphisms in

    http://iris.ucl.ac.uk/iris/publication/15438/1

  9. Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist...

    Genetically modified mice have been extensively used to study human disease. However, the data gained are not always translatable to humans because of major species differences. Liver-humanized mice (LHM) are considered a promising model to study

    http://iris.ucl.ac.uk/iris/publication/1731481/1

  10. Harnessing publicly available genetic data to prioritize lipid modifying therapeutic...

    Therapeutic interventions that lower LDL-cholesterol effectively reduce the risk of coronary artery disease (CAD). However, statins, the most widely prescribed LDL-cholesterol lowering drugs, increase diabetes risk. We used genome-wide association

    http://iris.ucl.ac.uk/iris/publication/1117781/1

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