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  1. DNA repair is limiting for haematopoietic stem cells during ageing.

    Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of ageing. Here we address this question by taking advantage of the highly specific role of DNA ligase IV in the repair of DNA

  2. Marked overlap of four genetic syndromes with dyskeratosis congenita confounds clinical...

    Dyskeratosis congenita is a highly pleotropic genetic disorder. This heterogeneity can lead to difficulties in making an accurate diagnosis and delays in appropriate management. The aim of this study was to determine the underlying genetic basis in

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