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1 - 10 of 22 results found for mtorc2.

  1. Autophagy and receptor tyrosine kinase signalling: A mTORC2 matter.

    http://iris.ucl.ac.uk/iris/publication/1423728/1

  2. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

    http://iris.ucl.ac.uk/iris/publication/1192531/1

  3. Rapamycin treatment increases mTORC2 activity and selectively activates the AKT1 isoform...

    http://iris.ucl.ac.uk/iris/publication/428691/11

  4. PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via...

    http://iris.ucl.ac.uk/iris/publication/1480303/3

  5. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in...

    http://iris.ucl.ac.uk/iris/publication/1294788/1

  6. The BardetBiedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts...

    http://iris.ucl.ac.uk/iris/publication/914116/11

  7. The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts...

    CCDC28B encodes a coiled coil domain-containing protein involved in ciliogenesis that was originally identified as a second site modifier of the ciliopathy Bardet-Biedl syndrome. We have previously shown that the depletion of CCDC28B leads to

    http://iris.ucl.ac.uk/iris/publication/877360/2

  8. The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 upregulation in...

    PURPOSE: The multikinase inhibitor sorafenib displays antitumor activity in preclinical models of osteosarcoma. However, in sorafenib-treated patients with metastatic-relapsed osteosarcoma, disease stabilization and tumor shrinkage were short-lived

    http://iris.ucl.ac.uk/iris/publication/1025786/2

  9. The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet.

    Signaling downstream of mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) controls specific and distinct aspects of insulin action and nutrient homeostasis in an interconnected and as yet unclear way. Mice lacking the mTORC1

    http://iris.ucl.ac.uk/iris/publication/1004849/2

  10. Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for...

    Importance: Randomized clinical trials have demonstrated a substantial benefit of adding everolimus to endocrine therapy. Everolimus inhibits the mammalian target of rapamycin complex 1 (mTORC1) complex but not mTORC2, which can set off an

    http://iris.ucl.ac.uk/iris/publication/1690627/1

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