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1 - 10 of 33 results found for tbk1.

  1. Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing...

  2. CS17-3. Vaccinia Virus Protein C6 is a Virulence Factor that Binds TBK1 Adaptor Proteins...


    26/domainex-announces-investment-round-to-progress-its-tbk1ikke-and-epigenetic-programmes/","title":{"rendered":"Domainex announces investment round to progress its TBK1/IKKe and epigenetic programmes"},"content":{"rendered":"p UCLB spinout

  4. The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated...

  5. Domainex announces investment round to progress its TBK1/IKKe and...

    The investment will be used to advance Domainex’ s kinase based drug development programmes against TBK1/IKKe and epigenetics targets. ... Dr Eddy Littler, CEO of Domainex said “ Over the last year Domainex’ s programmes targeting TBK1/IKKe have

  6. Regulation of intracellular traffic by TBK1 and its relevance to ALS

    Neurons are highly polarised cells, typically comprising a somatodendritic compartment and an axon that can extend for a meter or more. Their extreme morphology challenges neurons to establish an efficient communication system between the axonal

  7. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

    Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In this study, we

  8. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in...

    Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide phosphorylation

  9. TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

    The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF) signalling, linear (also known as M1) ubiquitin enables full gene activation and prevents cell death. However, the

  10. ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

    Mutations in TANK binding kinase 1 (TBK1) have been linked to amyotrophic lateral sclerosis. Some TBK1 variants are nonsense and are predicted to cause disease through haploinsufficiency; however, many other mutations are missense with unknown

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